Literature summary extracted from
Grant, J.E.; Guo, L.W.; Vestling, M.M.; Martemyanov, K.A.; Arshavsky, V.Y.; Ruoho, A.E.
The N terminus of GTP gamma S-activated transducin alpha-subunit interacts with the C terminus of the cGMP phosphodiesterase gamma-subunit (2006), J. Biol. Chem., 281, 6194-6202.
Activating Compound
EC Number |
Activating Compound |
Comment |
Organism |
Structure |
---|
3.1.4.35 |
alpha-subunit of transducin |
activation of isoform PDE6 by binding to the inhibitory gamma-subunit |
Bos taurus |
|
Localization
EC Number |
Localization |
Comment |
Organism |
GeneOntology No. |
Textmining |
---|
3.1.4.35 |
membrane |
of rod outer segment |
Bos taurus |
16020 |
- |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
3.1.4.35 |
Bos taurus |
- |
isoform PDE6 |
- |
Source Tissue
EC Number |
Source Tissue |
Comment |
Organism |
Textmining |
---|
3.1.4.35 |
retinal rod |
outer segment membrane |
Bos taurus |
- |
Subunits
EC Number |
Subunits |
Comment |
Organism |
---|
3.1.4.35 |
More |
alpha-subunit of transducin interacts with the inhibitory gamma subunit of PDE6 thereby activating the enzyme. Interaction requires activated alpha-subunit of transducin and involves the C-terminus of PDE6 gamma-subunit, particularly residue 73 |
Bos taurus |